<strike id="amuic"></strike>
  • <abbr id="amuic"><option id="amuic"></option></abbr>
    <strike id="amuic"></strike>
    

  • <cite id="amuic"><source id="amuic"></source></cite>

    <cite id="amuic"><source id="amuic"></source></cite>
    • <ul id="amuic"><table id="amuic"></table></ul>
    


    
    
    
        
        
    
    
    

    

    
    
    
    
    
        
        
    
    
        
    

    

    
    
    
    
    
        
        
    
    
    
    最近搜索：細胞培養(yǎng) 微生物學 分子生物 生物化學 
    

    

    
	
    首頁>>免疫學>>一抗>>干擾素調節(jié)因子2抗體  
    

    

    
	
    
    	
    
        	
    干擾素調節(jié)因子2抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
    • 
                        	
      產(chǎn)品貨號：
      
                            
      BN40480R
      
                        
      • 
                    	
    • 
                        	
      中文名稱：
      
                            
      干擾素調節(jié)因子2抗體 
      
                        
      • 
                                            	
    • 
                        	
      英文名稱：
      
                            
      Rabbit anti-IRF2 Polyclonal antibody 
      
                        
      • 
                                                                    	
    • 
                        	
      品牌：
      
                            
      Biorigin 
      
                        
      • 
                    
    
                
    
            
    
            
    
                    
    
                        
      
                            
    • 
                                
      貨號
      
                                
      產(chǎn)品規(guī)格
      
                                
      售價
      
                                
      備注
      
                            
      • 
                                                        
    • 
                                
      BN40480R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human,Mouse,Rat(predicted:Pig,Cow,Horse,Sheep)   推薦應用：IHC-P,IHC-F,ICC,IF,ELISA
      
                            
      • 
                                                        
    • 
                                
      BN40480R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human,Mouse,Rat(predicted:Pig,Cow,Horse,Sheep)   推薦應用：IHC-P,IHC-F,ICC,IF,ELISA
      
                            
      • 
                                                    
    
                    
    
              
    
            
    
            	
    
                	
    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱IRF2
    中文名稱干擾素調節(jié)因子2抗體
    別    名DKFZp686F0244; Interferon regulatory factor 2; IRF 2; IRF-2; IRF2; IRF2_HUMAN.  
    研究領域細胞生物  轉錄調節(jié)因子  表觀遺傳學  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Pig, Cow, Horse, Sheep, )
    產(chǎn)品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量39kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human IRF2:81-180/349 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]

    Function:
    Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.

    Subcellular Location:
    Nucleus.

    Tissue Specificity:
    Expressed throughout the epithelium of the colon. Also expressed in lamina propria.

    Post-translational modifications:
    Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.
    The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation by SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.

    Similarity:
    Belongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.

    SWISS:
    P14316

    Gene ID:
    3660

    Database links:
    Entrez Gene: 3660 Human
    Entrez Gene: 16363 Mouse
    Omim: 147576 Human
    SwissProt: P14316 Human
    SwissProt: P23906 Mouse
    Unigene: 654566 Human
    Unigene: 1149 Mouse


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














    image.png
    image.png
    image.png
    image.png
    image.png
    image.png
    image.png
    image.png
    image.png