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磷酸化G蛋白偶合受體激酶2抗體

產品貨號：

BN40479R
中文名稱：

磷酸化G蛋白偶合受體激酶2抗體
英文名稱：

Rabbit anti-phospho-GRK2 (Ser670) Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40479R-100ul

100ul

￥2470.00

交叉反應：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：IHC-F,IF,ELISA

產品描述

英文名稱	phospho-GRK2 (Ser670)
中文名稱	磷酸化G蛋白偶合受體激酶2抗體
別名	GRK2 (phospho S670); p-GRK2 (phospho S670); G-protein coupled receptor kinase 2; ADRBK 1; ADRBK1; Adrenergic beta receptor kinase 1; BARK 1; BARK; BARK1; Beta adrenergic receptor kinase 1; Beta ARK 1; Beta ARK1; G Protein Coupled Receptor Kinase 2; G protein dependent receptor kinase 2; FLJ16718; GRK 2; ARBK1_HUMAN.
產品類型	磷酸化抗體
研究領域	細胞生物神經生物學信號轉導激酶和磷酸酶 G蛋白偶聯受體 G蛋白信號
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, )
產品應用	ELISA=1:5000-10000 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	76kDa
細胞定位	細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthesised phosphopeptide derived from human GRK2 around the phosphorylation site of Ser670:PR(p-S)PV
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq]. Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Subunit: Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5. Interacts with ARRB1. Interacts with LPAR1 and LPAR2. Interacts with RALA in response to LPAR1 activation. ADRBK1 and RALA mutually inhibit each other's binding to LPAR1. Tissue Specificity: Expressed in peripheral blood leukocytes. Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 PH domain. Contains 1 protein kinase domain. Contains 1 RGS domain. SWISS: P25098 Gene ID: 156 Database links: Entrez Gene: 156 Human Entrez Gene: 25238 Rat Omim: 109635 Human SwissProt: P25098 Human SwissProt: Q99MK8 Mouse SwissProt: P26817 Rat Unigene: 83636 Human Unigene: 254144 Mouse Unigene: 13010 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.