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    首頁>>免疫學>>一抗>>磷酸化神經生長相關蛋白43抗體  
    

    

    
	
    
    	
    
        	
    磷酸化神經生長相關蛋白43抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN40472R
      
                        
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      中文名稱：
      
                            
      磷酸化神經生長相關蛋白43抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-phospho-GAP43 (Ser41) Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      BN40472R-100ul
      
                                
      100ul
      
                                
      ￥2470.00
      
                                
      交叉反應：Human,Mouse,Rat(predicted:Dog)   推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱phospho-GAP43 (Ser41)
    中文名稱磷酸化神經生長相關蛋白43抗體
    別    名GAP43 (phospho S41); p-GAP43 (phospho S41); Phospho-GAP43（pSer41）; GAP43 (Phospho-Ser41); p-GAP43 (Ser41); p-GAP43 (S41); Growth Associated Protein-43; Neuromodulin; Axonal membrane protein GAP 43; B-50; F1; GAP 43; Growth Associated Protein 43; Nerve Growth Related Peptide; Neural phosphoprotein B 50; Neuromodulin; GAP-43; pp46; NEUM_HUMAN; Protein F1; QtrA-11580; QtrA-13071.  
    產品類型磷酸化抗體 
    研究領域細胞生物  免疫學  神經生物學  信號轉導  細胞凋亡  轉錄調節因子  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Dog, )
    產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2g /test IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量46kDa
    細胞定位細胞漿 細胞膜 細胞外基質 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated Synthesised phosphopeptide derived from human GAP43 around the phosphorylation site of Ser41:QA(p-S)FR 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

    Function:
    This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

    Subunit:
    Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.

    Subcellular Location:
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium membrane; Peripheral membrane protein. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.

    Post-translational modifications:
    Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.
    Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2.

    Similarity:
    Belongs to the neuromodulin family.
    Contains 1 IQ domain.

    SWISS:
    P17677

    Gene ID:
    2596

    Database links:
    Entrez Gene: 2596 Human
    Entrez Gene: 14432 Mouse
    Entrez Gene: 29423 Rat
    GenBank: NP_002036 Human
    Omim: 162060 Human
    SwissProt: P17677 Human
    SwissProt: P06837 Mouse
    SwissProt: P07936 Rat
    Unigene: 134974 Human
    Unigene: 1222 Mouse
    Unigene: 10928 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.