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磷酸化周期素C抗體

產品貨號：

BN40443R
中文名稱：

磷酸化周期素C抗體
英文名稱：

Rabbit anti-phospho-Cyclin C (Ser275) Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40443R-100ul

100ul

￥2470.00

交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產品描述

英文名稱	phospho-Cyclin C (Ser275)
中文名稱	磷酸化周期素C抗體
別名	Cyclin C (phospho S275); p-Cyclin C (phospho S275); CCNC; CCNC_HUMAN; CycC; Cyclin C; Cyclin-C; CyclinC; hSRB11; OTTHUMP00000016897; SRB11 homolog
產品類型	磷酸化抗體
研究領域	細胞生物神經生物學信號轉導表觀遺傳學
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat, (predicted: Chicken, Dog, Cow, Horse, Sheep, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	33kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated Synthesised phosphopeptide derived from human Cyclin C around the phosphorylation site of Ser275:NG(p-S)QN
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Subcellular Location: Nucleus. Tissue Specificity: Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the cyclin family. Cyclin C subfamily. Contains 1 cyclin N-terminal domain. SWISS: P24863 Gene ID: 892 Database links: Entrez Gene: 892 Human Entrez Gene: 51813 Mouse Entrez Gene: 114839 Rat Omim: 123838 Human SwissProt: P24863 Human SwissProt: Q62447 Mouse SwissProt: P39947 Rat Unigene: 430646 Human Unigene: 278584 Mouse Unigene: 106758 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.