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    最近搜索：細胞培養 微生物學 分子生物 生物化學 
    

    

    
	
    首頁>>免疫學>>一抗>>鳥嘌呤核苷酸結合蛋白3樣蛋白抗體  
    

    

    
	
    
    	
    
        	
    鳥嘌呤核苷酸結合蛋白3樣蛋白抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN40424R
      
                        
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      中文名稱：
      
                            
      鳥嘌呤核苷酸結合蛋白3樣蛋白抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-GNL3L Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
      售價
      
                                
      備注
      
                            
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      BN40424R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit)   推薦應用：IHC-P,IHC-F,ICC,IF,ELISA
      
                            
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      BN40424R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit)   推薦應用：IHC-P,IHC-F,ICC,IF,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱GNL3L
    中文名稱鳥嘌呤核苷酸結合蛋白3樣蛋白抗體
    別    名GNL3L_HUMAN; FLJ10613; Guanine nucleotide binding protein-like 3 (nucleolar)-like; novel GTPase; OTTHUMP00000023374.  
    研究領域細胞生物  免疫學  染色質和核信號  G蛋白偶聯受體  G蛋白信號  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, )
    產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量66kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human GNL3L:210-310/582 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹GTPases from the MMR1/HSR1 GTP-binding protein subfamily are circularly rearranged G-motifs that play a critical role in maintaining normal cell growth. Deletion of these genes results in severe growth defects with a marked reduction in mature rRNA species and a concomitant accumulation of the 35S pre-rRNA transcript. Deletion also causes the ribosomal protein Rpl25a to fail exportation from the nucleolus. Deletion of any of the G-domain motifs will result in a null phenotype and nuclear/nucleolar localization that lacks the nucleolar export of preribosomes and is accompanied by a distortion of the nucleolar structure. GNL3L (guanine nucleotide binding protein-like 3 (nucleolar)-like) is a 582 amino acid nuclear protein that belongs to the MMR1/HSR1 GTP-binding protein family. Containing one G (guanine nucleotide-binding) domain, GNL3L is required for normal processing of ribosomal pre-rRNA and for cell proliferation.

    Function:
    Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.

    Subunit:
    Interacts with MDM2; this interaction, which occurs in the nucleoplasm, stabilizes MDM2. Indirectly interacts with TP53, via MDM2-binding. Interacts with TERF1; this interaction probably occurs in the nucleoplasm and is increased during mitosis, when the nucleolus is disassembled. This binding may promote TERF1 homodimerization. Interacts with TERT.

    Subcellular Location:
    Nucleus, nucleolus.

    Similarity:
    Belongs to the MMR1/HSR1 GTP-binding protein family.
    Contains 1 G (guanine nucleotide-binding) domain.

    SWISS:
    Q9NVN8

    Gene ID:
    54552

    Database links:
    Entrez Gene: 54552 Human
    SwissProt: Q9NVN8 Human


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


















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