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    首頁>>免疫學(xué)>>一抗>>雙特異性蛋白磷酸酶10抗體  
    

    

    
	
    
    	
    
        	
    雙特異性蛋白磷酸酶10抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號：
      
                            
      BN40403R
      
                        
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      中文名稱：
      
                            
      雙特異性蛋白磷酸酶10抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-DUSP10 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產(chǎn)品規(guī)格
      
                                
      售價(jià)
      
                                
      備注
      
                            
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      BN40403R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit)   推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA
      
                            
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      BN40403R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit)   推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱DUSP10
    中文名稱雙特異性蛋白磷酸酶10抗體
    別    名MKP5; MKP 5; MKP-5; Dual specificity phosphatase 10; Dual specificity phosphatase MKP 5; Dual specificity phosphatase MKP5; Dual specificity protein phosphatase 10; DUS10_HUMAN; DUSP 10; DUSP10; DUSP10 protein; MAP kinase phosphatase 5; Mitogen activated protein kinase phosphatase 5; Mitogen-activated protein kinase phosphatase 5; Serine/threonine specific protein phosphatase.  
    研究領(lǐng)域細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  激酶和磷酸酶  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量53kDa
    細(xì)胞定位細(xì)胞核 細(xì)胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human DUSP10/MKP5:161-260/482 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. MKP-5 preferentially binds to p38, but also to SAPK/JNK. It is ubiquitously expressed and localizes to both the cytoplasm and the nucleus. MKP-5 has been implicated in cell proliferation and apoptosis, tumor invasion and immune responses.

    Function:
    Involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily.

    Subunit:
    Monomer. Interacts with MAPK14.

    Subcellular Location:
    Cytoplasm. Nucleus.

    Tissue Specificity:
    Detected in brain.

    Similarity:
    Belongs to the protein-tyrosine phosphatase family.
    Non-receptor class dual specificity subfamily.
    Contains 1 rhodanese domain.
    Contains 1 tyrosine-protein phosphatase domain.

    SWISS:
    Q9Y6W6

    Gene ID:
    11221

    Database links:
    Entrez Gene: 11221 Human
    Entrez Gene: 63953 Mouse
    Entrez Gene: 63995 Rat
    Omim: 608867 Human
    SwissProt: Q9Y6W6 Human
    SwissProt: Q9ESS0 Mouse
    Unigene: 497822 Human
    Unigene: 404024 Mouse
    Unigene: 163239 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.