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    首頁>>免疫學>>一抗>>生長抑制因子基因1抗體  
    

    

    
	
    
    	
    
        	
    生長抑制因子基因1抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN40399R
      
                        
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      中文名稱：
      
                            
      生長抑制因子基因1抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-ING1 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      BN40399R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Mouse(predicted:Human,Rat)   推薦應用：WB,ELISA
      
                            
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      BN40399R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Mouse(predicted:Human,Rat)   推薦應用：WB,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱ING1
    中文名稱生長抑制因子基因1抗體
    別    名ING1_HUMAN; Inhibitor of growth protein 1; inhibitor of growth gene 1; Growth inhibitor ING 1; Growth inhibitor ING1; Growth inhibitory protein ING 1; Growth inhibitory protein ING1; Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds; ING 1; Inhibitor of growth 1; Inhibitor of growth family member 1; Inhibitor of growth protein 1; p24ING1c; p33 ING1; p33ING1; p33ING1b; p47ING1a; Tumor suppressor ING 1; Tumor suppressor ING1.  
    研究領域腫瘤  細胞生物  信號轉導  細胞凋亡  細胞周期蛋白  轉錄調節因子  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Mouse,  (predicted: Human, Rat, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量46kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human inhibitor of growth gene 1:301-422/422 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].

    Function:
    Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

    Subcellular Location:
    Nucleus.

    Tissue Specificity:
    Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.

    DISEASE:
    Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck.

    Similarity:
    Belongs to the ING family.
    Contains 1 PHD-type zinc finger.

    SWISS:
    Q9UK53

    Gene ID:
    3621

    Database links:
    Entrez Gene: 3621 Human
    Entrez Gene: 26356 Mouse
    Entrez Gene: 306626 Rat
    GenBank: NP_937862 Human
    Omim: 601566 Human
    SwissProt: Q9UK53 Human
    SwissProt: Q9QXV3 Mouse
    Unigene: 46700 Human
    Unigene: 508725 Human
    Unigene: 25709 Mouse


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    腫瘤的發生是一個多基因參與,多步驟發生的復雜過程，抑癌基因的功能失活與癌基因的激活為其主要原因之一。 ING1基因是近期發現的抑癌基因，研究發現，它的過表達可抑制細胞生長、增殖,促進細胞凋亡，它的低表達與腫瘤的發生、發展有關。ING1正常時定位于胞核，發揮其誘導凋亡和調控細胞周期的作用，當其易位于胞質時上述作用逐步減弱或消失，在腫瘤發生時，多位于胞漿。