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    首頁>>免疫學>>一抗>>磷酸化胰島素受體底物1抗體  
    

    

    
	
    
    	
    
        	
    磷酸化胰島素受體底物1抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN40387R
      
                        
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      中文名稱：
      
                            
      磷酸化胰島素受體底物1抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-phospho-IRS1 (Ser616) Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      產品規格
      
                                
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      BN40387R-100ul
      
                                
      100ul
      
                                
      ￥2470.00
      
                                
      交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep)   推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱phospho-IRS1 (Ser616)
    中文名稱磷酸化胰島素受體底物1抗體
    別    名IRS1 (phospho S616); p-IRS1 (phospho S616); HIRS 1; HIRS1; Insulin Receptor Substrate 1; IRS 1; IRS-1; IRS1; IRS1_HUMAN; OTTHUMP00000164234  
    產品類型磷酸化抗體 
    研究領域細胞生物  免疫學  神經生物學  細胞凋亡  糖尿病  細胞類型標志物  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量131kDa
    細胞定位細胞核 細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthesised phosphopeptide derived from human IRS1 around the phosphorylation site of Ser616:PM(p-S)PG 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]

    Function:
    May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

    Subunit:
    Interacts with UBTF and PIK3CA (By similarity). Interacts (via phosphorylated YXXM motifs) with PIK3R1 (By similarity). Interacts with ROCK1 and FER (By similarity). Interacts (via PH domain) with PHIP (By similarity). Interacts with GRB2 (By similarity). Interacts with SOCS7. Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif). Interacts with ALK. Interacts with EIF2AK2/PKR (By similarity).

    Post-translational modifications:
    Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor. Phosphorylation of Tyr-896 is required for GRB2-binding.

    DISEASE:
    Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].

    Similarity:
    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.

    SWISS:
    P35568

    Gene ID:
    3667

    Database links:
    Entrez Gene: 3667 Human
    Entrez Gene: 16367 Mouse
    Entrez Gene: 25467 Rat
    Omim: 147545 Human
    SwissProt: P35568 Human
    SwissProt: P35569 Mouse
    SwissProt: P35570 Rat
    Unigene: 471508 Human
    Unigene: 4952 Mouse
    Unigene: 10476 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.