中文亚洲av片不卡在线观看,亚洲中文无码a∨在线观看,中文字幕精品无码亚洲字

<strike id="amuic"></strike>

<abbr id="amuic"><option id="amuic"></option></abbr>

<strike id="amuic"></strike>

<cite id="amuic"><source id="amuic"></source></cite>

<cite id="amuic"><source id="amuic"></source></cite>

<ul id="amuic"><table id="amuic"></table></ul>

最近搜索：細(xì)胞培養(yǎng) 微生物學(xué) 分子生物生物化學(xué)

首頁>>免疫學(xué)>>一抗>>ALKB蛋白抗體

ALKB蛋白抗體

產(chǎn)品貨號：

BN40375R
中文名稱：

ALKB蛋白抗體
英文名稱：

Rabbit anti-ABH1 Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價(jià)

備注
BN40375R-100ul

100ul

￥2360.00

交叉反應(yīng)：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA
BN40375R-200ul

200ul

￥3490.00

交叉反應(yīng)：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱	ABH1
中文名稱	ALKB蛋白抗體
別名	ABH; ABH1; alkB; AlkB, alkylation repair homolog 1 (E. coli); ALKB1_HUMAN; ALKBH; ALKBH1; Alkylated DNA repair protein alkB homolog 1; Alkylation repair homolog 1; Alkylation repair, alkB homolog; Alpha-ketoglutarate-dependent dioxygenase ABH1; DNA lyase ABH1; hABH.
研究領(lǐng)域	腫瘤神經(jīng)生物學(xué) 表觀遺傳學(xué)
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應(yīng)	Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	44kDa
細(xì)胞定位	細(xì)胞核細(xì)胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human ABH1/ALKB:1-100/389
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	ALKB protects DNA and RNA against damage from methylating compounds from the environment by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzymes act by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate, and molecular oxygen as the oxidizing agent. Deficiencies in DNA and RNA repair in mammals are associated with cancer, neurological disease and developmental defects. ALKB plays a role in resistance to anti-cancer drugs which attempt to damage tumor DNA. Escherichia coli ALKB protein belongs to the superfamily of 2-oxoglutarate- and iron(II)-dependent oxygenases. Function: Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron. Subunit: Monomer. Interacts with DNAJB6 (By similarity). Subcellular Location: Mitochondrion. Nucleus. Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli. Tissue Specificity: Ubiquitous. Similarity: Belongs to the alkB family. Contains 1 Fe2OG dioxygenase domain. SWISS: Q13686 Gene ID: 8846 Database links: Entrez Gene: 8846 Human Entrez Gene: 211064 Mouse Omim: 605345 Human SwissProt: Q13686 Human SwissProt: P0CB42 Mouse Unigene: 94542 Human Unigene: 26840 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.