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    最近搜索：細胞培養 微生物學 分子生物 生物化學 
    

    

    
	
    首頁>>免疫學>>一抗>>紅細胞分化相關基因蛋白抗體  
    

    

    
	
    
    	
    
        	
    紅細胞分化相關基因蛋白抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN40360R
      
                        
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      中文名稱：
      
                            
      紅細胞分化相關基因蛋白抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-Hemogen Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      BN40360R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：nan(predicted:Human)   推薦應用：WB,ELISA
      
                            
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      BN40360R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：nan(predicted:Human)   推薦應用：WB,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱Hemogen
    中文名稱紅細胞分化相關基因蛋白抗體
    別    名EDAG; EDAG-1; Erythroid differentiation-associated gene protein; HEMGN; HEMGN_HUMAN; Hemogen; Hemopoietic gene protein; Negative differentiation regulator protein.  
    研究領域腫瘤  細胞生物  免疫學  細胞分化  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(predicted: Human, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量55kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Hemogen/EDAG:51-150/484 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Hemogen is a 484 amino acid protein encoded by the human gene HEMGN. Hemogen is a nuclear protein that is expressed in hematopoietic precursor cells and can be detected in CD34+ and K-562 leukemia cell line. It is also expressed in bone marrow, testis, thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia. Hemogen is down-regulated during megakaryocytic differentiation of K-562 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) (at protein level). It can be up-regulated in normal PBMCs by mitogens.

    Function:
    Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).

    Subcellular Location:
    Nucleus.

    Tissue Specificity:
    Expressed in fetal liver, kidney and brain. Expressed in hematopoietic precursor cells (at protein level). Detected in CD34+ and K562 leukemia cell line (at protein level). Expressed in bone marrow, testis, thymus. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia.

    SWISS:
    Q9BXL5

    Gene ID:
    55363

    Database links:
    Entrez Gene: 55363 Human
    Omim: 610715 Human
    SwissProt: Q9BXL5 Human
    Unigene: 176626 Human


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.