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    首頁>>免疫學>>一抗>>神經(jīng)腫瘤Nova1抗原抗體  
    

    

    
	
    
    	
    
        	
    神經(jīng)腫瘤Nova1抗原抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號：
      
                            
      BN40301R
      
                        
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      中文名稱：
      
                            
      神經(jīng)腫瘤Nova1抗原抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-Nova1 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產(chǎn)品規(guī)格
      
                                
      售價
      
                                
      備注
      
                            
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      BN40301R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human,Mouse,Rat(predicted:Chicken,Cow)   推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA
      
                            
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      BN40301R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human,Mouse,Rat(predicted:Chicken,Cow)   推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱Nova1
    中文名稱神經(jīng)腫瘤Nova1抗原抗體
    別    名Neuro oncological ventral antigen 1; Neuro-oncological ventral antigen 1; NOVA 1; Nova-1; Nova1; NOVA1_HUMAN; Onconeural ventral antigen 1; Paraneoplastic Ri antigen; RNA binding protein Nova 1; RNA-binding protein Nova-1; Ventral neuron specific protein 1; Ventral neuron-specific protein 1.  
    研究領(lǐng)域腫瘤  細胞生物  神經(jīng)生物學  細胞類型標志物  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Chicken, Cow, )
    產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量52kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Nova1:411-510/510 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹Nova-1 and Nova-2 are members of a superfamily of protein regulators of RNA metabolism in neurons. Both are nuclear RNA binding proteins with K homology motifs, conserved protein sequences which bind to RNA (1,2). Nova proteins, normally sequestered in the central nervous system, are expressed by systemic tumors in patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA) (3,4). Nova-1 is expressed in the hindbrain and ventral spinal cord and Nova-2 is expressed in the neocortex and hippocampus (4). Nova-1 is necessary for regulating neuron-specific alternative splicing of the glycine receptor Alpha2 pre-mRNA (5).

    Function:
    May regulate RNA splicing or metabolism in a specific subset of developing neurons.

    Subunit:
    Interacts with PTBP2; the interaction is direct (By similarity).

    Subcellular Location:
    Nucleus.

    Tissue Specificity:
    Brain.

    Similarity:
    Contains 3 KH domains.

    SWISS:
    P51513

    Gene ID:
    4857

    Database links:
    Entrez Gene: 4857 Human
    Entrez Gene: 664883 Mouse
    Entrez Gene: 298992 Rat
    Omim: 602157 Human
    SwissProt: Q2PFW9 Cynomolgus monkey
    SwissProt: P51513 Human
    SwissProt: Q9JKN6 Mouse
    SwissProt: Q80WA4 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications