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    首頁>>免疫學>>一抗>>β2-微球蛋白抗體  
    

    

    
	
    
    	
    
        	
    β2-微球蛋白抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN40212R
      
                        
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      中文名稱：
      
                            
      β2-微球蛋白抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-beta 2 Microglobulin Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      BN40212R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human   推薦應用：WB,ELISA
      
                            
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      BN40212R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human   推薦應用：WB,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱beta 2 Microglobulin
    中文名稱β2-微球蛋白抗體
    別    名B2M; Beta-2-MG; Beta 2 microglobulin precursor; Beta chain of mhc class 1 proteins; Hdcma22p; B2MG_HUMAN; Beta-2 microglobin; Beta 2 microglobulin precursor; Beta chain of mhc class 1 proteins; Beta chain of MHC class I molecules; Beta-2-microglobulin form pI 5.3; CDABP0092.  
    研究領域細胞生物  免疫學  淋巴細胞  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, 
    產品應用WB=1:500-2000 ELISA=1:5000-10000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量13/27kDa
    細胞定位分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原Recombinant human Beta-2-Microglobulin protein: 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009].

    Function:
    Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

    Subunit:
    Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis.

    Subcellular Location:
    Secreted. Note=Detected in serum and urine.

    Post-translational modifications:
    Glycation of Ile-21 is observed in long-term hemodialysis patients.

    DISEASE:
    Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
    Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.

    Similarity:
    Belongs to the beta-2-microglobulin family.
    Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

    SWISS:
    P61769

    Gene ID:
    567

    Database links:
    Entrez Gene: 567 Human
    Entrez Gene: 12010 Mouse
    Entrez Gene: 24223 Rat
    Omim: 109700 Human
    SwissProt: P61769 Human
    SwissProt: P01887 Mouse
    SwissProt: P07151 Rat
    Unigene: 534255 Human
    Unigene: 702947 Human
    Unigene: 163 Mouse
    Unigene: 1868 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    小鼠抗人β2微球蛋白在中樞神經系統感染、腫瘤及全身性自身免疫性疾病患者腦脊液中，會出現β